3-aryl-1, 5-iminocycloalkanes and preparation thereof



United States Patent 3,133,073 3-ARYL-1,5-0CYCLOALKANES AND PREPARATION THEREOF Sydney Archer, Bethlehem, N.Y., assignor to Sterling Drug Inc, New York, N.Y., a corporation of Delaware No Drawing. Filed Dec. 10, 1959, Ser. No. 858,560 8 Claims. (Cl. 260-292) This invention relates to bicyclic amino compounds and in particular is concerned with 1,5-iminocycloalkanes, monosubstituted in the 3-position by monocyclic aryl, and the preparation thereof.

In the 3-(monocyclic aryl)-1,5-iminocycloalkanes of the invention, the cycloalkane preferably has seven or eight ring members. The compounds preferably thus contain the ring structure of cycloheptane or cyclooctane. The cycloalkane ring carbon atoms can be substituted by conventional radicals such as lower-alkyl and lower-alkoxy. The nitrogen atom-of the 1,5-irnino bridge can be unsubstituted, or substituted by a hydrocarbon radical free of ethylenic or acetylenic unsaturation, or by such radicals substituted by conventional substituents such as halogen or lower-alkoxy.

Pharmacological evaluation of the compounds of the invention has demonstrated that they cause an increase in the blood pressure and are useful as central nervous sys tem stimulants.

A particular aspect of the invention relates to 3-(monocyclic aryl) substituted tropanes and granatanines having the general formula (I) wherein Ar represents monocyclic aryl, R represents hydrogen, lower-alkyl or monocarbocyclic aryl-lower-alkyl, R and R represent hydrogen or lower-alkoxy, and n is or 1. It is preferred that when n is 1 R and R represent hydrogen.

In the above general Formula I, Ar represents a monocyclic aryl radical and thus stands for a phenyl ring or an aromatic-type heterocyclic ring, optionally substituted by conventional groups inert under the conditions of the processes used to prepare the compounds. A preferred class for Ar comprises phenyl, thienyl, pyridyl and furyl, and such rings substituted by from one to three radicals selected from lower-alkyl, lower-alkoxy, halogen (including fluorine, chlorine, bromine and iodine), loWer-alkylmercapto and trifluoromethyl. The lower-alkyl, loweralkoxy and lower-alkylmercapto radicals contain from one to about four carbon atoms, thus including, inter alia, methyl, ethyl, propyl, isopropyl, butyl, methoxy, ethoxy, propoxy, isopropoxy, butoxy, methylmercapto, ethylmercapto and butylmercapto.

In the above general Formula I, R represents hydrogen, lower-alkyl or monocarbocyclic aryl-lower-alkyl. The term lower-alkyl here stands for an alkyl radical or bridge of from one to about eight carbon atoms. The term monocarbocyclic ary stands for the same types of radicals defined above for Ar except that heterocyclic radicals are excepted. R thus stands for such radicals as methyl, ethyl, propyl, isopropyl, butyl, hexyl, octyl, benzyl, Z-phenylethyl, 4-phenylbutyl, p-tolylmethyl, p methoxyphenylmethyl, 2-chlorobenzyl, and the like. The radical R preferably has no more than about ten carbon atoms.

In the above general Formula I, R and R represent hydrogen or lower-alkoxy radicals and can be the same or different. When R and R represent lower-alkoxy ice they contain from one to about four carbon atoms and thus stand for such radicals as methox, ethoxy, propoxy, isopropoxy, butoxy and the like.

Referring to the above general Formula I, the compounds where n is 0 belong to the tropane series whereas the compounds where n is 1 belong to the granatanine series. In these compounds there is a possibility of stereoisornerism depending upon whether the substituent in the 3-position, Ar, is on the same side (beta configuraa tion) or the opposite side (alpha configuration) of the molecule as the N-R bridge. In the tropane series these stereoisomers are known as tropanes and pseudotropanes, respectively.

The compounds of the invention are prepared as follows:

A 3a-hydroxy-3fl-(monocyclic aryl) substitutedLS-iminocycloalkane (II) heated with Raney nickel catalyst undergoes dehydroxylation with retention of configuration to give a compound of Formula I of the pseudo (5) series. If, however, the aryl carbinol (II) is first dehydrated, as by treatment with thionyl chloride to replace the hydroxyl radical by chlorine followed by dehydrochlorination with an alkali metal hydroxide, and the resulting 3-aryl-1,5-imino-2-cycloalkene (III) is then hydrogenated catalytically, a compound of Formula I of opposite configuration [normal (a) series] is obtained.

The Raney nickel dehydroxylation of the aryl carbinol (II) takes place in an inert solvent at a temperature between about 50 C. and 150 C. The reduction is brought about by residual hydrogen in the catalyst. A preferred inert solvent is a lower-alkanol.

The catalytic hydrogenation of the 3-aryl-1,5-imino-2- cycloalkene (III) takes place in an inert solvent at temperatures between about 20 C. and C. The catalyst can be any of those known to be effective in reducing ethylenic linkages of the styrene type, including such catalysts as Raney nickel, platinum oxide, nickel on kieselguhr, copper-aluminum oxide, and the like.

The intermediate aryl carbinols of Formula II are readily prepared by reacting under anhydrous conditions the corresponding 3-oxo compound with an organornetallic compound, ArM, wherein M is a metal-containing moiety such as bromomagnesium or lithium, and hydrolyzing the intermediate complex. The 3-oxo compounds in turn are prepared by the classic Robinson synthesis, i.e., condensation of succindialdehyde, glutaric dialdehyde or derivatives thereof with a primary amine (RNH and acetonedicarboxylic acid ester (EtOOCCI-I COCH -COOEt), followed by hydrolysis and decarboxylation.

The acid-addition salts and the quaternary ammonium salts of the bases herein described are the form in which the bases are most conveniently prepared for use and are the full equivalents of the subject matter specifically claimed. The preferred salts are water-soluble pharmacologically acceptable salts, that is, salts whose anions are relatively innocuous to the animal organism in pharmacological doses of the salts, so that the beneficial physiological properties inherent in the free base are not vitiated by side effects ascribable to the anions; in other words t latter do not substantially affect the pharmacological properties inherent in the cations. In practicing the inven tion, it has been found convenient to form the hydrochloride salt. However, other appropriate pharmacologically acceptable salts within the scope of the invention are those of mineral acids such as hydrobromic acid, hydriodic acid, nitric acid, phosphoric acid, sulfamic acid, and sulfuric acid; and organic acids such as acetic acid, citric acid, tartaric acid, lactic acid, methanesulfonic acid, ethanesulfonic acid, quinic acid, and the like, giving the hydrobromide, hydriodide, nitrate, phosphate, sulfamate, sulfate, acetate, citrate, tartrate, lactate, methanesulfonate, ethane sulfonate, and quinate salts, respectively. The quaternary ammonium salts are obtained by the addition of esters having a molecular weight less than about 200 to the free base form of the compounds. A preferred class of esters comprises lower-alkyl', lower-alkenyl or monocarbocyclic aryl-lower-alkyl esters of inorganic acids or organic sulfonic acids, and includes such compounds as methyl chloride, methyl bromide, methyl iodide, ethyl bromide, propyl chloride, Z-hydroxyethyl bromide, "allyl chloride, allyl bromide, methyl sulfate, methyl benzenesulfonate, methyl p-toluenesulfonate, benzyl chloride, benzyl bromide, and substituted benzyl halides, such as p-chlorobenzyl chloride, p-nitrobenzyl chloride, o-chlorobenzyl chloride, p-methoxybenzyl chloride, and the like.

The quaternary ammonium salts are prepared by mixing the free base and the alkyl, a kenyl or aralkyl esters in an organic solvent inert under the conditions of reaction, for example, ethanol, methanol, ether, acetonitrile and the like. Heating can be used to facilitate the reaction, although salt formation usually takes place readily at room temperature. The quaternary ammonium salt separates directly or can be obtained by concentration of the solution.

Although pharmacologically acceptable salts are preferred, those having toxic anions are also useful. All acid-addition salts are useful as intermediates in purification of the free base form even if the particular salt per se is not desired as the final product, as for example when the salt is formed only for purposes of purification or identification, or when it is used as an intermediate in preparing a pharmacologically acceptable salt by ion exchange procedures. Similarly, the quaternary ammonium salts, regardless of the nature of the anions, are useful in characterization of the free base forms, or as intermediates in the formation of other quaternary ammonium salts by ion exchange procedures.

The structure of the compounds of the invention is established by the mode of synthesis and by chemical analysis. The assignment of configuration of the stereoisomers of compounds of Formula I was based upon the fact that the =Raney nickel dehydroxylation of 3-phenyltropine would be expected to proceed with retention of configuration, whereas the hydrogenation of 3-phenyltropidine would preferentially take place by addition of hydrogen at the less hindered side of the molecule, leading to the compound of configuration opposite to that of the dehydroxylation reaction product.

The following examples will illustrate the invention without limiting the latter thereto.

Example 1 3,6-phenylzropane [1; Ar is C H (pl-series), R is CH R' and R" are H, n is 0].Moist Raney nickel catalyst (90 g.) was covered with 125 ml. of ethanol and 6.0 g. of 3fi-phenyl-3a-hydroxytropane was added to the suspension. iThe mixture was refluxed for four hours, then filtered and the catalyst washed with fresh alcohol. The combined filtrates were concentrated and the residue was distilled to give 4.2 g. of 3fi-phenyltropane in the form of an oil, B.P. 92-94 C. (0.2 mm).

A portion of the foregoing product was converted to the hydrochloride salt by dissolving it in ether and treating the solution with an excess of ethanolic hydrogen chlobe 0.77:0.06 mg./kg. in terms of the free base.

The picrate of 3fi-phen-yltropane was prepared by treat: ing a solution of the free base with a solution of an excess of picric acid in ethanol. The picrate was separated and recrystallized from aqueous dimethylformamide, giving a sample having the M.P. 211.5-213" C. (uncorr.).

Analysis .Calcd. for C H N.C H N O I C, 55.68; H, 5.38. Found: C, 56.39; H, 5.08.

The methiodide salt of 3p-phenyltropane was prepared by treating a solution of 3 fi-phenyltropane (prepared from 250 mg. of the hydrochloride salt) in 2 ml. of acetonitrile with 5 ml. of methyl iodide. The crystalline product which separated was collected by filtration, recrystallized from water and dried at 50 C.

3fl-phenyltropane methiodide when administered intravenously to dogs at a dose level of 0.10-0.15 ing/kg. of body weight, caused an increase of 20-60 mg. Hg in blood pressure. The acute intravenous toxicity (LD of 35- phenyltropane methiodide in mice was found to be 3.17:0.23 ing/kg. in terms of the cation.

Example 2 3a-phenyltr0pane [1; Ar is C H (oi-series), R is CH R and R are H, n is 0] .A solution of 32.7 g. of 3- phenyltropidine in ethanol was hydrogenated at 50 C. in the presence of Raney nickel catalyst at 1000 lbs. per sq. inch. After hydrogenation was complete (about onehalf hour) the mixture was filtered and the filtrate was concentrated to dryness. The residue was distilled .giv ing 3ot-phenyltropane in the form of an oil, B.P. 128-131 0. 2.0 mm.) which solidified upon standing, M1? 55- 57 C. after recrystallization from hexane.

Similar results were obtained when the Raney nickel was replaced by platinum oxide catalyst.

A solution of the 3u-phenyltropane obtained above was dissolved in ether and converted to the hydrochloride salt with ethanolic hydrogen chloride. The Sa-phenyItropane hydrochloride thus obtained had the MP. 217.4218.8 C. -'(dec.) (corn) after recrystallization from isopropyl alcohol. A mixed melting point of 3m-phenyltropane hydrochloride and 3fi-phenyltropane hydrochloride (Ex ample 1) showed a depression to C.

Analysis.Calcd. for C H N.HCl: C, 70.70; H, 8.49; N, 5.89. Found: C, 70.90; H, 8.47; N, 5.91.

3u-phenyltropane hydrochloride when administered in: travenously to dogs at a dose level of 0.30-0.60 ing/kg. of body weight, caused an increase of 20-40 mg. Hg in blood pressure. The acute intravenous toxicity (LD of 3ot-phenyltropane hydrochloride in mice was found to be 4.9105 mg./kg. in terms of the free base.

The picrate of 3a-phenyltropane, prepared from a sample of the free base and an excess of ethanolic picric acid had the M1. 196-197 C. (uncoriz).

Analysis.-Calcd. for C H N.C H N O C, 55.68; H, 5.38. Found: C, 55.85; H, 5.20.

The methiodide salt of 3a-phenyltropane was prepared from 3.33 :g. of 3m-phenyltropane and 1.57 g. of methyl iodide in 15 ml. of acetonitrile. After one hour at room temperature the solid product which had separated was collected by filtration and recrystallized from ethanol to give 4.2 g. of Ba-phenyltropane methiodide, M. P. 298.2- 300.2 C. (corn).

' then cooled and the solid product collected by filtration.

After recrystallization from absolute ethanol there was obtained 2.6 g. of 3a-phenyltropane 2-chlorobenzochloride, M.P. 234.6-235.4 C. (corr.).

Analysis.-Calcd. for C H C1 N: N, 3.87; Cl, 19.57. Found: N, 3.86; Cl, 19.60.

Example 3 (a) 3fi-(4-br0m0phenyl)-3a-hydr0xytr0pane.-n-Butyl bromide (20.6 g.) in 30 ml. of dry ether was added dropwise to a suspension of 2.58 g. of lithium wire in 90 ml. of dry ether stirred in a nitrogen atmosphere at 10 C. The mixture was allowed to Warm up to 20 C. over a period of two hours, and then a solution of 35.4 g. of pdibromobenzene in 120 ml. of dry ether was added drop- Wise at a rate so as to maintain gentle refluxing. The resulting mixture was refluxed for one-half hour longer, and then there was added dropwise 21 g. of 3-tropanone in 100 ml. of dry ether. The final mixture was allowed to stand at room temperature for about fifteen hours and then refluxed for three hours. Water (120 ml.) was gradually added, and the solid product was collected by filtration and recrystallized from aqueous ethanol using activated charcoal for decolorizing purposes. There was thus obtained 6.7g. of 3B-(4-bromophenyD-3whydroxytropane, M.P. 197.2-200.4 C. (corr.).

Analysis.-Calcd. for C H BrNO: N, 4.73; Br, 26.98. Found: N, 4.71; Br, 27.15.

The methiodide salt of 3,8-(4-bromophenyl)-3a-hydroxytropane was prepared from 3.26 g. of the free base and 1.57 g. of methyl iodide in 100 ml. of absolute ethanol. Upon standing at room temperature the solid product separated and was collected by filtration and recrystallized from ethanol to give 3.7 g. of 3p-(4-bromophenyl)-3a-hydroxytropane methiodide, M.P. 298.0 300 C. (corr.)..

Analysis.Calcd. for C H BrINO: N, 3.20; I, 29.0. Found: N, 3.18; I, 28.7.

(b) 3 3-(4-brom0phenyl)tropane [1; Ar is 4BrC H 5- series), R is CH R and R" are H, n is can be prepared by heating 3fi-(4-b-romophenyl)-3a-hydroxytropane with Raney nickel catalyst according to the manipulative procedure described above in Example 1.

Example 4 (a) 3-(4-l7r0m0phenyl)tropidine can be prepared by the following procedure: 3,8 (4-bromophenyl)-3oc-hydroxytropane is gradually added to a solution of an excess of thionyl chloride in anhydrous ether, while being cooled in an ice-salt bath. The resulting solution is warmed at about 50 C. for thirty minutes and the excess thionyl chloride and ether are removed by distillation in vacuo. The residue is dissolved in ethanol and treated with an excess of concentrated aqueous potassium hydroxide. The resulting product is isolated and purified by distillation.

(b) 3a-(4-bromophenyl)tropzme [1; Ar is 4-BrC H (oz-series), R is CH R and R" are H, n is 0] can be prepared by catalytic hydrogenation of- 3-(4-bromophenyl)-tropidine according to the manipulative procedure described above in Example 2.

Example (a) 313 phenyl-3a-hyd r0xyn0rtr0pane was prepared from 20 g. of 3-oxonor-tropane and phenyllithium, derived from 62.8 g. of bromobenzene and 5.55 g. of lithium, according to the manipulative procedure described above in Example 3, part (a). There was thus obtained 35- phenyl-3a-hydroxynortropane in the form of its hydrochloride salt, M.P. 237.7238.l C. (corr.).

Analysis.-Calcd. for C H NO.HCl: C, 65.22; H, 7.62; Cl, 14.51. Found: C, 65.20; H, 7.78; Cl, 14.60.

(b) .ifi-phenylnortropane [I; Ar is C H (5-Series), R, R" and R are H, n is 0] can be prepared by heating 36- phenyl-3e-hydroxynortropane with Raney nickel catalyst according to the manipulative procedure described above I in Example 1.

Example 6 (a) 3-phenylnortropidine can be prepared by dehydration of 35-phenyl-3a-hydroxynortropane according to the procedure described above in Example 4, part (a).

(b) 3a-phenyln0rtropane [1; Ar is C H (0L-S1'iES), R, R' and R" are H, n is 0] can be prepared by catalytic hydrogenation of 3-phenylnortropidine according to the manipulative procedure described above in Example 2.

Example 7 (a) 3/3-(4-methylphenyl)-3u-hydr0xytr0pane can be prepared by replacing the p-dibromobenzene in Example 3, part (a), with a molar equivalentamount of p-tolyl bromide.

(b) 3fl-(4-methylphenyl)tropane [1; Ar is 4-CH C H R is CH R and R are H, n is 0] can be prepared by replacing the 3fl-phenyl-3a-hydroxytropane in Example 1 with a molar equivalent amount of 3fi-(4-methylphenyl)- 3a-hydroxytropane.

Example 8 (a) 3,8-(2-ethylphenyl)-3a-lzyzlr0xytr0pnne can be prepared by replacing the p-dibromobenzene in Example 3, part (a), with a molar equivalent amount of 2-ethylphenyl bromide.

(b) 3fl-(2-ethylphenyl) tropane [1; Ar is 2-C H C H R is CH R and R- are H, n is 0] can be prepared by replacing the 3B-phenyl-3 et-hydroxytropane in Example 1 with a molar equivalent amount of 3,8-(2-ethylphenyl)- 3a-hydroxyt'ropane.

Example 9 (a) 3fi-(2,4-dimethylphenyl)-3a hydroxytropane can be prepared by replacing the p-dibromobenzene in Example 3, part (a), with a molar equivalent amount of 2,4- dimethylphenyl bromide.

(b) 3/3(2,4-dimezhylphenyl)tropane [1; Ar is 2,4- (CH C H R is CH R and R are H, n is 0] can be prepared by, replacing the 3fl-phenyl-3et-hydroxytropane in Example 1 with a molar equivalent amount of 3B- (2,4-dimethylphenyl) -3 ot-hydroxytropane.

Example 10 (a) 3,8-(2,4,6-trimethylphenyl)don-hydroxytropane can be prepared by replacing the p-dibromobenzene in Example 3, part (a), with a molar equivalent amount of mesityl bromide.

(b) 3(3-(2,4,6-trimethylphenyl)tropane [1; Ar is 2,4,6- (CH C H R is CH R and R are H, n is 0 can be prepared by replacing the 3B-phenyl-3oz-hydroxytropane in Example 1 with a molar equivalent amount of 3,8- 2,4,6-trimethylphenyl) -3 oc-hYdIOXYtIOPfiIlC.

Example 11 (a) dfl-( l-methoxyphenyl)-3oc-hydroxytropane can be prepared by replacing the p-dibromobenzene in Example 3, part (a), with a molar equivalent amount ofp-methoxyphenyl bromide.

(b) 35 (4 -metho-xyphenyl)tropane [1; Ar is 4- CH OC H R is CH R and R are H, n is 0] can be prepared by replacing the 3fi-phenyl-3a hydroxytropane in Example 1 with a molar equivalent amount of 35-(4- methoxyphenyl -3 u-hydroxytropane.

Example 12 (a) 3B-(4-butoxyphenyl)-3oe-hydr0xytr0pane can be prepared by replacing the p-dibromobenzene in Example 3, part (a), with a molar equivalent amount of 4-butoxyphenyl bromide.

7 V (b) 3B-(4-but0xyphenyl) tropane [1; Ar is R is'CH R and R are H, n is can be prepared by prepared by replacing the p-dibromobenzene in Example 1 with a molar equivalent amount of 3 3-(4-butoxyphenyl) -3 a-hydroxytropane.

Example 13 (a) 3fl-(3,4-dimethoxyphenyl)-3a-hydr0xytr0pane can be prepared by replacing the p-dibrornobenzene in Example 3, part (a), with a molar equivalent amount of 3,4- dimeth'oxyphenyl bromide.

(b) 3;8-(3,4-dimeth0xyphenyl)tropane [1; Ar is 3,4 (CH O) C H R is CH R and R are H, n is 0] can be=prepared by replacing the 3B-phenyl-3a-hydroxytro pane in Example 1 with a molar equivalent amount of 3 3- 3 ,4-dimethoxyphenyl) -3 a-hydroxytropane.

Example 14 (a) .ifl-(3,4,5-trimetlzoxyphenyl) -30: hydroxytropane can be prepared by replacing the p-dibromobenzene in Example 3 part (a), with a molar equivalent amount of 3,4,5 -trirnethoxyphenyl bromide. I

(b) 313-(3,4,5 trimethoxyphenyl)tropane [1; Ar is 3,4,5-(CH O) C H R is CH R and R are H, n is 01 can be prepared by replacing the 3f3-phenyl-3 ot-hydroxytropane in Example 1 with a molar equivalent amount of 3/3- (3 ,4,5-trimethoxyphenyl) -3 a-hydroxytropane.

Example 15 (a) 3fl-(4-flu0rophenyD-3a-hydr0xytropane can be prepared by replacing the p-dibromobenzene in Example 3, part (a), with a molar equivalent amount of 4'-fluor0 phenyl bromide.

(b) 3 3-(4-fla0r0phenyl) tropane [1; Ar is 4-FC H R is CH R and R are H, n is 0] can be prepared by replacing the 3,6-phenyl-3 oz-hydroxytropane in Example I with a molar equivalent amount of 3fi-(4-fluorophenyl)- 3e-hydroxytropane.

Example 16 (a) 3B-(4-chl0r0phenyl)-3ot-hydr0xytr0pane can be prepared by replacing the p-dibromobenzene in Example 3, part (a), with a molar equivalent amount of 4- chlorophenyl bromide.

(b) 3 3-(4-chl0r0phenyl)tr0pane [1; Ar is 4-ClC 1-I R is CH R and R are H, n is 0] can be prepared by replacing the 313-phenyl-3 a-hydroxytropane in Example 1 with a molar equivalent amount of 3,8-(4-chl0rophenyl)- 3a-hydr0xytropane.

Example 17 (a) 35-(4-1'0dophenyl)-3a-hydr0xytr0pane can be prepared by replacing the p-dibromobenzene in Example 3, part (a), with a molar equivalent amount of p-diiodobenzene.

(b) 35-(4-i0d0phenyl)tropane [I; Ar is 4-IC 1-I R is CH R and R" are H, n is 0] can be prepared by replacing the 3,8-phenyl-3a-hydroxytropane in Example 1 with a molar equivalent amount of 3[3-(4-iodophenyl)-3a-hydroxytropane.

Example 18 (a) 313-(4-methylmercaptophenyl)-3rxhydroxytropane can be prepared by replacing the p-dibromobenzene in Example 3, part (a), with a molar equivalent amount of 4-methylmercaptophenyl bromide.

(b) 3B-(4-methylmercaptophenyl) tropane [1; A1 is 4-CH SC H R is CH R and R" are H, n is O] can be prepared by replacing the 3fl-phenyl-3a-hydroxytropane in Example 1 With a molar equivalent amount of 3,8-(4- methylmercaptophenyl) -3 a-hydroxytropane.

Example 19 (a) 3,8-(3-trifiu0r0methylplzenyl)-3a hydroxyzropane can be prepared by replacing the p-dibromobenzene in 8 Example 3, part (a), with a molar equivalent'amount of B-trifiuoromethylphenyl bromide. v (b) 3/3-(3-trifluoromethylplzenyl)tropane [1; Ar is 3-F CC H R is CH R and R are H, n is 0] can be prepared by replacing the 313-phenyl-3a-hydroxytropane in Example 1 with a molar equivalent amount of 3,8-(3- trifluoromethylphenyl -3 a-hydroxytropane.

Example 20 (a) 3B-(Z-pyridyl)-3a-hydroxytropane can be prepared by replacing the p-dibromobenzene in Example3, part (a), with a molar equivalent amount of 2-bromopyridine.

(b) 3fl-(2-pyridyl)tropane [1; Ar is Z-pyridyl, R is CH R and R are H, n is 0] can be prepared by replacing the 3,6-phenyl-3a hydroxytropane in Example 1 with a molar equivalent amount of ,3{3-(2-pyrldyl)-3ix-. hydroxytropane. Example 21 (a) 3fl-(2-rhienyl)-3a-hydr0xytropane can be prepared by replacing the p-dibromobenzene in Example 3, part (a), with a molar equivalent amount of 2-bromothioe phene.

(b) 3fl-(2-thienyl)tropane [1, Ar is Z-thienyl, R is CH R and R are H, n is 0] can be prepared by replacing the 3p-pl1enyl-3a-hydroxytropane in Example 1 with a molar equivalent amount of 3p-(2-thienyl)-3a-hydroxytropane.

Example 22 (a) Sfl-(Z-furyl)-3a-hydroxytr0pane can be prepared by replacing the p-dibromobenzene in Example 3, part (a), with a molar equivalent amount of 2-bromofuran. Y

(b) 35-(2-juryl)tr0pane [1; AI is Z-furyl, R is CH R and R" are H, n is 0] can be prepared by replacing the 3fl-phenyl-3a-hydroxytropane in Example 1 with a molar equivalent amount of 3fi-(2-furyl)-3 z-hydroxytropane.

Example 23 Example 24 I (a) .ifl-phenyla-hydroxy-6-melhoxytropane can be prepared by replacing the p-dibromobenzene and the 3- tropanone in Example 3, part (a), with molar equivalent amounts of bromobenzene and 6-methoxy-3-oxotropane, respectively.

(b) 3fl-phenyl-6-methoxytropane [1; Ar is C H R CH R is C11 0, R" is H, n'is 0] can be prepared by replacing the 3fl-phenyl-3ot-hydroxytropane in Example 1 with a molar equivalent amount of 3 3-phenyl-3a-hydroxy- 6-methoxytropane.

Example 25 (a) 3,6-phenyl-3u-hydroxy 6,7 dimethoxytropane can be prepared by replacing the p-dibromobenzene and the 3-tropanone in Example 3, part (a), with molar equivalent amounts of bromobenzene and 6,7-dimethoxy-3-oxotropane, respectively. 1

(b) 3fl-phenyl-6,7-dimeth0xytr0pane [1; Ar is C HS, R'- is CH R and R are CH O, n is 0] can be prepared by replacing the 3fl-phenyl-3u-hydroxytropane in Example 1 with a molar equivalent amount of 3fl-phenyl-3 a-hydroxy 6,7-dimethoxytropane.

Example 26 (a) 3,8-phenyl-3a-kya'roxy-8-benzylnortropane can be prepared by replacing the p-dibromobenzene and the 3 tropanone in Example 3, part (a), with molar equivalent amounts of bromobenzene and 8-benzyl-3-oxonortropane, respectively.

(b) 3fl-phenyl-8-benzyln0rtr0pane [I; Ar is C H R is C H CH R and R" are H, n is can be prepared by replacing the 3 8-phenyl-3a-hydroxytropane in Example 1 with a molar equivalent amount of 3 fi-phenyl-3 a-hydroxy- S-benzylnortropane.

' Example 27 (a) SB-phenyl-3a-hydr0xy-8-(4 meth0xybenzyl)n0rtropane can be prepared by replacing the p-dibromobenzene and the 3-tropanone in Example 3, part (a), with molar equivalent amounts of bromobenzene and 8-(4- methoxybenzyl)-3-oxonortropane, respectively.

(b) 3,8-phenyl-8-(4-methoxybenzyl)nortropane [I; Ar is C H R is 4-CH OC H CH R and R are H, n is 0] can be prepared by replacing the 3/3-phenyl-3a-hydr0xytropane in Example 1 with a molar equivalent amount of 3fi-phenyl-3a-hydroxy-S-(4-methoxybenzyl)nortropane.

Example 28 (a) 3 8-phenyl-3a-hydr0xy-8 (2,3 dimethoxybenzyl) nortropane can be prepared by replacing the p-dibromobenzene and the 3-tropanone in Example 3, part (a), with molar equivalent amounts of bromobenzene and 8- (2,3-dimethoxybenzyl)-3-oxonortropane, respectively.

(b) 3B-phenyl-8-(2,3-dimethoxybenzyl)nortropane [1; Ar is C H R is 2,3-(CH O) C H CH R and R" are H, n is O] can be prepared by replacing the 3 3-phenyl-3ahydroxytropane in Example 1 with a molar equivalent amount of BB- henyI-Sa-hydrOXy-S-(2,3-dimethoxybenzyl) nortropane.

Example 29 (a) 35-phenyl-3a-hydr0xy 8 (4 chlorobenzyl)n0rtropane can be prepared by replacing the p-dibromobenzene and the 3-tropanone in Example 3, part (a), with molar equivalent amounts of bromobenzene and 8-(4- chlorobenzyl)-3-oxonortropane, respectively.

(b) 3B-phenyl-8-(4-chl0r0benzyl)nortropane [1; Ar is C H R is 4-ClC H CH R and R" are H, n is O can be prepared by replacing the 3/3-phenyl-3a-hydroxytropane in Example 1 with a molar equivalent amount of 3/8-phenyl-3a-hydroxy-8-(4-chlorobenzyl)nortropane.

Example 30 (a) 3fl-phenyl-3a-hydroxy 8 (2,4 dichlorobenzyl) nortropane can be prepared by replacing the pdibromo benzene and the 3-tropanone in Example 3, part (a), with molar equivalent amounts of bromobenzene and 8-(2,4- dichlorobenzyl)-3-oxonortropane, respectively.

(b) 3,8-phenyl-8-(2,4-dichl0r0benzyl)nortropane [1; Ar is C H R is 2,4-CI C H CH R and R" are H, n is 0] can be prepared by replacing the 3/3-phenyl-3a-hydroxytropane in Example 1 with a molar equivalent amount of 3B-phenyl-3a-hydroxy-8-(2,4-dichlorobenzyl)nortropane.

Example 31 (a) 3fi-phenyl-3a-hydroxy-8-propyl 6 methoxynortropane can be prepared by replacing the p-dibromobenzene and the 3-tropanone in Example 3, part (a), with molar equivalent amounts of bromobenzene and 8-propyl-. 6-methoxy-3-oxonortropane, respectively.

(b) 35-phenyl-8-pr0pyl-6-methoxynortropane [1; Ar is C H R is CH CH CH R is CH O, R is H, n is 0] can be prepared by replacing the 3,8-phenyl-3a-hydroxytropane in Example 1 with a molar equivalent amount of 3l3-phenyl-3a-hydroxy-8-propyl-6-methoxynortropane.

Example 32 (a) Bfl-phenyla-hydroxy 8 butyl 6 ethoxynortropane can be prepared by replacing the p-dibromobenzene and the 3-.tropanone in Example 3, part (a), with molar equivalent amounts of bromobenzene and 8-butyl-6- ethoxy-3 -oxonortropane, respectively.

(b) 35-phenyl-8-butyl-6-eth0xyn0rtr0pane [1; Ar is C H R is CH CH CH CH R is C H O, R" is H,

10? n is 0] can be prepared by replacing the 3 fi-phenyl-ilahydroxytropane in Example 1 with a molar equivalent amount of 3,8-phenyl-3a-hydroxy-8-butyl-6-ethoxynortropane.

Example 33 3p-phenyl-N-methylgra'natanine [I; Ar is C H R is CH R and R are H, n is 1] can be prepared by replacing the 3p-phenyl-3a-hydroxytropane in Example 1 with a molar equivalent amount of 3,8-phenyl-3u-hydroxy- N-methylgranatanine.

Example 34 (a) 3,3-phenyl-3a-hydroxy-8-0ctylnortr0pane can be prepared by replacing the p-dibromobenzene and the 3- tropanone in Example 3, part (a), with molar equivalent RCH CH-CH;

(GHQ) 11 R-N CH-Ar R-CH GEL-CH;

wherein Ar is a member of the group consisting of phenyl, thienyl, pyridyl and furyl and these rings substituted by from one to three substituents selected from the group consisting of lower-alkyl, lower-alkoxy, halogen, loweralkylmercapto and trifluoromethyl; R is a member of the group consisting of hydrogen, lower-alkyl and monocarbocyclic aryl-lower-alkyl, wherein monocarbocyclic aryl is a member of the group consisting of phenyl and phenyl substituted by from one to three substituents selected from the group consisting of lower-alkyl, loweralkoxy, halogen, lower-alkylmercapto and trifluoromethyl,

R and R" are members of the group consisting of hydrogen and loWer-alkoxy and n is selected from 0 and 1.

2. 3-phenyl-8-lower-alkyl-nortropane.

3. Sfi-phenyltropane.

4. 3a-phenyltropane.

5. The process for preparing a compound having the formula wherein Ar is a member of the group consisting of phenyl, thienyl, pyridyl and furyl and these rings substituted by from one to three substituents selected from the group consisting of loWer-alkyl, lower-alkoxy, halogen, lower-alkylmercapto and trifluoromethyl in the fi-configuration with respect to R, R is a member of the group consisting of hydrogen, lower-alkyl and monocarbocyclic aryl-loweralkyl, wherein monocarbocyclic aryl is a member of the group consisting of phenyl and phenyl substituted by from one to three substituents selected from the group consisting of lower-alkyl, lower-alkoxy, halogen, lower-alkylmercapto and trifluoromethyl, R and R" are members of the group consisting of hydrogen and lower-alkoxy, and n is selected from 0 and 1, which comprises heating a compound having the formula with Raney nickel catalyst in an inert solvent.

wherein AI is a member of the group consisting of phenyl', thienyl, pyridyl and furyland these rings substituted by from one to three substituents selected from the group consisting of lower-alkyl, lower-alkoxy, halogen, loweralkylmercapto and trifiuorometh'yl in the (configuration with respect to R, R is a'member of the group consisting of hydrogen, lower-alkyl and monocarbocyclic aryl-loweralkyl, wherein monocarbocyclic aryl is a member of the group consisting of phenyl and phenyl substituted by from one to three substituents selected from the group consisting of lower-alkyl, lower-'alkoxy, halogen, lower-alkylmercapto and trifluoromethyl, R and R" are members of 1 Raney nickel-catalyst in an inert solvent.

the group consisting of hydrogen and lower-alkoxy, and

n is selected from 0 and 1, which comprises catalytically hydrogenating a compound having the formula i 7. The process for preparing 3/3-phenyltropane which comprises heating 3fl-phenyl-3a hydroxytropane with 8. The process'for preparing 3a-pl1enyltropane which comprises catalytically hydrogeneting 3-phenyltro1;)iclin.

References Cited in the fileof this patent FOREIGN PATENTS Great Britain Oct. 4, 1950,

OTHER REFERENCES Cope et aL: I. Am. Chem. Soc., vol. 73, pp. 34 19 Gyerrnek: Chem. Abstracts, vol; 49, col. 14197 1955 UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Patent No. 3, 133,073 May 12 1964 Sydney Archer that error appears in the above numbered pat- It is hereby certified that the said Letters Patent should read as ent requiring correction and corrected below.

Column 2 line 18 for "-HgC read -H O column 2 line 5, for "prepared by replacing the pdibr0m0benzene". read replacing the 35-pheny1-3 d-hyd'roxytropane Signed and sealed this 15th day of September 1964.

(SEAL) Attest:

EDWARD J. BRENNER ERNEST W. SWIDER Commissioner of Patents Attesting Officer 

1. A COMPOUND HAVING THE FORMULA 